Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 11/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103068 | 0.91 | GABRA2 (0.64) | GABRA2GABRA3GABRA1GABRA5 | |
| SCHEMBL8103380 | 0.86 | GABRA3 (0.56) | GABRA2GABRA3GABRA1GABRA5 | |
| SCHEMBL8096736 | 0.86 | GABRA3 (0.67) | GABRA2GABRA3GABRA1GABRA5 | |
| SCHEMBL8094738 | 0.83 | GABRA2 (0.61) | GABRA2GABRA3GABRA1GABRA5 | |
| SCHEMBL8103362 | 0.82 | GABRA2 (0.65) | GABRA2GABRA3GABRA1GABRA5 | |
| SCHEMBL8101039 | 0.80 | GABRA3 (0.52) | GABRA2GABRA3GABRA1GABRA5 | |
| SCHEMBL9001329 | 0.79 | GABRA1 (1.00) | GABRA2GABRA3GABRA1GABRA5 | |
| SCHEMBL8103227 | 0.77 | GABRA3 (0.52) | GABRA2GABRA3GABRA1GABRA5 | |
| SCHEMBL8885602 | 0.76 | GABRA3 (0.51) | GABRA2GABRA3GABRA1GABRA5 | |
| SCHEMBL8094714 | 0.76 | GABRA2 (0.64) | GABRA2GABRA3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5426186-A | Diagnosis, treatment of anxiety, sleep and seizure disorders, benzodiazepine overdose; enhancement of alertness | NEUROGEN CORPORATION (US) | 1995-06-20 | — | — | US | claimed |
| EP-0547168-A1 | CERTAIN CYCLOALKYL IMIDAZOPYRIMIDINES, A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1993-06-23 | — | — | EP | claimed |
| WO-1992004351-A1 | CERTAIN CYCLOALKYL IMIDAZOPYRIMIDINES, A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1992-03-19 | — | — | WO | claimed |
| US-6013799-A | HIGHLY SELECTIVE AGONISTS, ANTAGONISTS OR INVERSE AGONISTS FOR G-AMINOBUTYRIC ACID (GABA) BRAIN RECEPTORS; USEFUL IN DIAGNOSIS/TREATMENT OF ANXIETY, SLEEP, AND SEIZURE DISORDERS, DRUG OVERDOSE, AND ALERTNESS ENHANCEMENT ALERTNESS | NEUROGEN CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |
| US-5696260-A | AGONSIT, ANTAGONIST, PRODRUG; USEFUL IN DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP, SEIZURE DISORDER, OVERDOSE WITH BENZODIAZEPINE TYPE DRUGS AND ENHANCEMENT OF ALERTNESS | NEUROGEN CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |
| US-5426186-A | Diagnosis, treatment of anxiety, sleep and seizure disorders, benzodiazepine overdose; enhancement of alertness | NEUROGEN CORPORATION (US) | 1995-06-20 | — | — | US | disclosed |