Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA3 | P34903 | 7/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096736 | 0.83 | GABRA3 (0.67) | GABRA3GABRA2GABRA1GABRA5 | |
| SCHEMBL8103227 | 0.83 | GABRA3 (0.52) | GABRA3GABRA2GABRA1GABRA5 | |
| SCHEMBL9001266 | 0.80 | GABRA1 (0.75) | GABRA3GABRA2GABRA1GABRA5 | |
| SCHEMBL8094714 | 0.80 | GABRA2 (0.64) | GABRA3GABRA2GABRA1GABRA5 | |
| SCHEMBL8097270 | 0.80 | GABRA1 (0.63) | GABRA3GABRA2GABRA1GABRA5 | |
| SCHEMBL8103380 | 0.79 | GABRA3 (0.56) | GABRA3GABRA2GABRA1GABRA5 | |
| SCHEMBL8096416 | 0.78 | GABRA1 (0.67) | GABRA3GABRA2GABRA1GABRA5 | |
| SCHEMBL8088084 | 0.76 | GABRA2 (0.64) | GABRA3GABRA2GABRA1GABRA5 | |
| SCHEMBL8103068 | 0.76 | GABRA2 (0.64) | GABRA3GABRA2GABRA1GABRA5 | |
| SCHEMBL8094738 | 0.75 | GABRA2 (0.61) | GABRA3GABRA2GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185446-A | Treating anxiety, sleep, seizure disorders | NEUROGEN CORPORATION (US) | 1993-02-09 | — | — | US | claimed |
| US-5696260-A | AGONSIT, ANTAGONIST, PRODRUG; USEFUL IN DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP, SEIZURE DISORDER, OVERDOSE WITH BENZODIAZEPINE TYPE DRUGS AND ENHANCEMENT OF ALERTNESS | NEUROGEN CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |
| US-5426186-A | Diagnosis, treatment of anxiety, sleep and seizure disorders, benzodiazepine overdose; enhancement of alertness | NEUROGEN CORPORATION (US) | 1995-06-20 | — | — | US | disclosed |
| US-5185446-A | Treating anxiety, sleep, seizure disorders | NEUROGEN CORPORATION (US) | 1993-02-09 | — | — | US | disclosed |