Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088849 | 1.00 | FFAR1 (0.48) | FFAR1MTNR1AMTNR1BRPS6KB1F2R | |
| SCHEMBL8089150 | 0.86 | HTR2A (0.55) | MTNR1AMTNR1BHTR2AHTR2CHTR2B | |
| SCHEMBL8088925 | 0.86 | HTR2A (0.55) | MTNR1AMTNR1BHTR2AHTR2CHTR2B | |
| SCHEMBL8102619 | 0.85 | MTNR1A (0.48) | FFAR1MTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL9019866 | 0.84 | MTNR1A (0.50) | FFAR1MTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL9019865 | 0.84 | MTNR1A (0.50) | FFAR1MTNR1AMTNR1BHTR2AHTR2C | |
| SCHEMBL8095712 | 0.83 | HTR2A (0.53) | MTNR1AMTNR1BRPS6KB1HTR2AHTR2C | |
| SCHEMBL8095710 | 0.83 | HTR2A (0.53) | MTNR1AMTNR1BRPS6KB1HTR2AHTR2C | |
| SCHEMBL8104774 | 0.82 | CNR2 (0.48) | MTNR1AMTNR1B | |
| SCHEMBL8104776 | 0.82 | CNR2 (0.48) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | claimed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | claimed |