Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 12/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093145 | 0.91 | MAPT (0.39) | NAMPTPIK3CDPIK3CAMTOR | |
| SCHEMBL8093138 | 0.89 | NAMPT (0.40) | NAMPTPIK3CDPIK3CAMTOR | |
| SCHEMBL8090705 | 0.89 | NAMPT (0.40) | NAMPTPIK3CDPIK3CAMTOR | |
| SCHEMBL8099965 | 0.89 | NAMPT (0.39) | NAMPTPIK3CDPIK3CACASR | |
| SCHEMBL8097253 | 0.87 | PIK3CD (0.36) | NAMPTPIK3CDPIK3CAMTOR | |
| SCHEMBL8097712 | 0.87 | KMT2A (0.39) | NAMPTPIK3CDPIK3CAKDREPHB4 | |
| SCHEMBL8091502 | 0.87 | NAMPT (0.39) | NAMPTPIK3CDPIK3CA | |
| SCHEMBL8093534 | 0.86 | NAMPT (0.41) | NAMPTPIK3CDPIK3CAMTOR | |
| SCHEMBL8084982 | 0.86 | KIF11 (0.38) | NAMPTKDREPHB4TEK | |
| SCHEMBL8093179 | 0.85 | RAB9A (0.42) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |