Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.36 |
| ▸ | TEK | Q02763 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 4/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083200 | 0.90 | ALDH1A1 (0.43) | KIF11CSF1RNAMPTCA12CA1 | |
| SCHEMBL8097712 | 0.90 | KMT2A (0.39) | CSF1RKDREPHB4TEKNAMPT | |
| SCHEMBL8097966 | 0.88 | KIF11 (0.37) | KIF11NAMPTALDH1A1MEN1KMT2A | |
| SCHEMBL8093179 | 0.87 | RAB9A (0.42) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL8093138 | 0.87 | NAMPT (0.40) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL8090705 | 0.87 | NAMPT (0.40) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL8091293 | 0.86 | MAPT (0.42) | KIF11NAMPTCA1CA2ALDH1A1 | |
| SCHEMBL8089216 | 0.86 | NAMPT (0.41) | KDREPHB4TEKNAMPT | |
| SCHEMBL8085029 | 0.86 | KIF11 (0.38) | KIF11CA1CA2ALDH1A1MEN1 | |
| SCHEMBL8082685 | 0.86 | IDO1 (0.40) | ALDH1A1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |