Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 7/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091502 | 0.91 | NAMPT (0.39) | PIK3CDPIK3CAROCK2ROCK1NAMPT | |
| SCHEMBL8090837 | 0.89 | MTOR (0.38) | PIK3CDPIK3CAROCK2ROCK1NAMPT | |
| SCHEMBL8099965 | 0.88 | NAMPT (0.39) | PIK3CDPIK3CANAMPTMAPT | |
| SCHEMBL8089216 | 0.87 | NAMPT (0.41) | PIK3CDPIK3CANAMPTMTOR | |
| SCHEMBL8093534 | 0.87 | NAMPT (0.41) | PIK3CDPIK3CAROCK2NAMPTMAPT | |
| SCHEMBL8090834 | 0.86 | KIF11 (0.35) | PIK3CDMAPTMEN1KMT2A | |
| SCHEMBL8099251 | 0.85 | NAMPT (0.38) | PIK3CDPIK3CANAMPTMAPTMTOR | |
| SCHEMBL8097714 | 0.85 | NAMPT (0.39) | PIK3CDPIK3CANAMPTMAPTKMT2A | |
| SCHEMBL8093145 | 0.85 | MAPT (0.39) | PIK3CDPIK3CANAMPTMAPTMTOR | |
| SCHEMBL8084284 | 0.85 | NAMPT (0.39) | PIK3CDPIK3CANAMPTMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |