SCHEMBL808923

SCHEMBL808923

COC(=O)C1C(C=C(F)Br)C1(C)C

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.44
TDP1 Q9NUW8 3/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TSHR P16473 3/20 0.34
CYP1A2 P05177 2/20 0.34
CYP2C19 P33261 2/20 0.34
NPSR1 Q6W5P4 1/20 0.31
ATM Q13315 2/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2D6 P10635 1/20 0.30
CYP2C9 P11712 1/20 0.30
TRPV1 Q8NER1 1/20 0.30
ADRA2A P08913 1/20 0.30
CNR1 P21554 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3358252 1.00 LMNA (0.44) LMNATDP1MEN1KMT2ATSHR
SCHEMBL11401859 0.86 LMNA (0.41) LMNATDP1MEN1KMT2ATSHR
SCHEMBL10828300 0.85 LMNA (0.50) LMNATDP1MEN1KMT2ATSHR
SCHEMBL808908 0.85 LMNA (0.46) LMNATDP1MEN1KMT2ATSHR
SCHEMBL9862228 0.85 LMNA (0.50) LMNATDP1MEN1KMT2ATSHR
SCHEMBL808904 0.85 LMNA (0.50) LMNATDP1MEN1KMT2ATSHR
SCHEMBL809024 0.84 LMNA (0.49) LMNATDP1MEN1KMT2ATSHR
SCHEMBL7639324 0.84 LMNA (0.49) LMNATDP1MEN1KMT2ATSHR
SCHEMBL7633174 0.84 LMNA (0.49) LMNATDP1MEN1KMT2ATSHR
SCHEMBL809025 0.84 LMNA (0.49) LMNATDP1MEN1KMT2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1783111-B1 METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLATE COMPOUND SUMITOMO CHEMICAL CO (JP) 2015-04-08 EP disclosed
CN-1852887-B Process for producing optically active cyclopropane compound and asymmetric copper complex for use in the same SUMITOMO CO LTD 2012-08-15 CN disclosed
EP-1607136-B1 OPTICALLY ACTIVE COPPER CATALYST COMPOSITION SUMITOMO CHEMICAL CO (JP) 2012-05-23 EP disclosed
EP-1593674-B1 OPTICALLY ACTIVE BISOXAZOLINE COMPOUNDS, PROCESS FOR PRODUCTION OF THE SAME AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2011-07-20 EP disclosed
US-7709651-B2 asymmetriccomplex of copper(I) trifluoromethanesulfonate and 1,1-bis[2-[(4S)-(tert-butyl)-oxazoline]]cyclopropane is added to 3-methyl-2-butenyl acetate and ethyl diazoacetate using dichloroethane solvent to effect reaction to produce ethyl 3,3-dimethyl-2-(acetoxymethyl)cyclopropanecarboxylate SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-05-04 US disclosed
US-7705165-B2 Method for producing optically active cyclopropanecarboxylate compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-27 US disclosed
US-7683215-B2 Optically active bisoxazoline compounds, process for production of the same and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-03-23 US disclosed
US-7671213-B2 Optically active bisoxazoline compounds, process for production of the same and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-03-02 US disclosed
EP-1783130-B1 METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLATE COMPOUND SUMITOMO CHEMICAL CO (JP) 2009-12-30 EP disclosed
CN-100569729-C The method for preparing optically active cyclopropanecarboxylcompound compound SUMITOMO CHEMICAL CO (JP) 2009-12-16 CN disclosed
EP-1783111-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLATE COMPOUND Sumitomo Chemical Company, Limited (JP) 2007-05-09 EP disclosed
EP-1783130-A1 METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLATE COMPOUND Sumitomo Chemical Company, Limited (JP) 2007-05-09 EP disclosed
US-20070032659-A1 Process for producing optically active cyclopropane compound and asymmetric copper complex for use in the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-02-08 US disclosed
CN-1852887-A Process for producing optically active cyclopropane compound and asymmetric copper complex for use in the same SUMITOMO CHEMICAL CO (JP) 2006-10-25 CN disclosed
US-20060211879-A1 Optically active copper catalyst composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-21 US disclosed
US-20060149077-A1 Optically active bisoxazoline compounds, process for production of the same and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-07-06 US disclosed
CN-1798609-A optically active copper catalyst composition SUMITOMO CHEMICAL CO (JP) 2006-07-05 CN disclosed
CN-1771236-A Optically active bisoxazoline compound, process for producing the same, and use thereof SUMITOMO CHEMICAL CO (JP) 2006-05-10 CN disclosed
EP-1607136-A1 OPTICALLY ACTIVE COPPER CATALYST COMPOSITION Sumitomo Chemical Company, Limited (JP) 2005-12-21 EP disclosed
EP-1593674-A1 OPTICALLY ACTIVE BISOXAZOLINE COMPOUNDS, PROCESS FOR PRODUCTION OF THE SAME AND USE THEREOF Sumitomo Chemical Company, Limited (JP) 2005-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060149077-A1 Optically active bisoxazoline compounds, process for production of the same and use thereof ACSL3, ADSL, SQLE LMNA 2541/4885TDP1 4483/4885MEN1 3119/4885
US-20070032659-A1 Process for producing optically active cyclopropane compound and asymmetric copper complex for use in the same CBR3, AOC3, CBR1 LMNA 4237/4885TDP1 4291/4885MEN1 2761/4885
US-20060211879-A1 Optically active copper catalyst composition CCNL2, HACL2, ARL1 LMNA 2648/4885TDP1 3416/4885MEN1 3298/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.