Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1362096 | 0.86 | HSD17B1 (0.47) | MAPTHSD17B1SMN1; SMN2CYP2A6RAB9A | |
| SCHEMBL8531963 | 0.80 | CA12 (0.50) | MAPTSMN1; SMN2RAB9ANPC1TDP1 | |
| SCHEMBL102139 | 0.79 | TDP1 (0.36) | SMN1; SMN2CYP2A6RAB9ANPC1MAPK1 | |
| SCHEMBL8529101 | 0.79 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2RAB9ANPC1TDP1 | |
| SCHEMBL3547261 | 0.78 | ACHE (0.41) | HSD17B1RAB9ANPC1MAPK1MAOB | |
| SCHEMBL15819482 | 0.78 | MAPT (0.44) | MAPTHSD17B1SMN1; SMN2ALDH1A1KIF11 | |
| SCHEMBL6611172 | 0.75 | MAPT (0.57) | MAPTHSD17B1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL15821343 | 0.75 | ALDH1A1 (0.43) | MAPTSMN1; SMN2RAB9ANPC1BRD4 | |
| SCHEMBL4125762 | 0.74 | MAOB (0.37) | MAPTSMN1; SMN2RAB9ANPC1TDP1 | |
| SCHEMBL2154312 | 0.74 | AHR (0.34) | MAPTSMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051394-A1 | POTASSIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037607-A1 | POTASSIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 1999-07-29 | — | — | WO | disclosed |