SCHEMBL8090154

SCHEMBL8090154

CC1(C)C=C(n2cc(N)cc(Br)c2=O)c2cc([N+](=O)[O-])ccc2O1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.34
CYP3A4 P08684 3/20 0.34
ALDH1A1 P00352 2/20 0.34
CHEK1 O14757 1/20 0.33
PIM1 P11309 1/20 0.33
LIMK1 P53667 1/20 0.33
TYRO3 Q06418 1/20 0.33
MAPK14 Q16539 1/20 0.33
CLK4 Q9HAZ1 1/20 0.33
CASP3 P42574 2/20 0.32
CASP1 P29466 1/20 0.32
CASP4 P49662 1/20 0.32
CASP7 P55210 1/20 0.32
CASP9 P55211 1/20 0.32
CASP6 P55212 1/20 0.32
PTPRC P08575 1/20 0.32
S100A4 P26447 1/20 0.32
NR3C1 P04150 1/20 0.32
PGR P06401 1/20 0.32
NR3C2 P08235 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8084409 0.90 ALDH1A1 (0.35) TDP1CYP3A4ALDH1A1CHEK1PIM1
SCHEMBL8085303 0.89 CHRM2 (0.34) TDP1CYP3A4ALDH1A1CHEK1PIM1
SCHEMBL8088693 0.88 PDE7A (0.33) TDP1CYP3A4ALDH1A1CASP3CASP1
SCHEMBL8085225 0.85 TDP1 (0.36) TDP1CYP3A4ALDH1A1CHEK1PIM1
SCHEMBL8077069 0.84 ALDH1A1 (0.35) TDP1CYP3A4ALDH1A1CASP3CASP1
SCHEMBL8090476 0.82 SMN1; SMN2 (0.38) TDP1CYP3A4ALDH1A1MEN1KMT2A
SCHEMBL8085257 0.82 MEN1 (0.34) TDP1CYP3A4ALDH1A1CHEK1PIM1
SCHEMBL8084458 0.81 TDP1 (0.34) TDP1CYP3A4ALDH1A1CASP3CASP1
SCHEMBL8084279 0.81 PDE4A (0.44) MALT1LMNAABCC9
SCHEMBL8085338 0.81 KMT2A (0.38) TDP1CYP3A4ALDH1A1CASP3CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6153627-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-11-28 US disclosed
US-6040308-A Chroman derivatives MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-03-21 US disclosed
US-5387587-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1995-02-07 US disclosed
EP-0273262-A2 Chroman derivatives MERCK PATENT GmbH (DE) 1988-07-06 EP disclosed