Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP4 | P49662 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP9 | P55211 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085257 | 0.90 | MEN1 (0.34) | KMT2AMEN1ADORA2BALDH1A1TDP1 | |
| SCHEMBL8089644 | 0.90 | MEN1 (0.34) | KMT2AMEN1ADORA2BALDH1A1TDP1 | |
| SCHEMBL8084409 | 0.88 | ALDH1A1 (0.35) | KMT2AMEN1ALDH1A1TDP1CYP3A4 | |
| SCHEMBL8085331 | 0.88 | HSD17B10 (0.38) | KMT2AMEN1ALDH1A1TDP1CYP3A4 | |
| SCHEMBL8088704 | 0.87 | ABCC9 (0.40) | KMT2AMEN1TDP1MAPK1MALT1 | |
| SCHEMBL8206417 | 0.87 | MEN1 (0.35) | KMT2AMEN1ADORA2BALDH1A1TDP1 | |
| SCHEMBL8090699 | 0.85 | ALDH1A1 (0.37) | KMT2AMEN1ADORA2BALDH1A1TDP1 | |
| SCHEMBL7291279 | 0.85 | ADORA2B (0.31) | KMT2AMEN1ADORA2BALDH1A1MAPT | |
| SCHEMBL8085035 | 0.85 | ALDH1A1 (0.38) | KMT2AMEN1ALDH1A1TDP1CYP3A4 | |
| SCHEMBL7291070 | 0.84 | CCNC (0.35) | KMT2AMEN1ADORA2BALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |