SCHEMBL8090463

SCHEMBL8090463

CC1=C(n2ccccc2=O)c2cc([N+](=O)[O-])ccc2OC12CCCCC2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 1/20 0.37
MAPK1 P28482 1/20 0.36
HTT P42858 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36
ALDH1A1 P00352 5/20 0.35
NPY5R Q15761 1/20 0.34
PTPRC P08575 2/20 0.33
BCHE P06276 1/20 0.33
ACHE P22303 1/20 0.33
CES1 P23141 1/20 0.33
S100A4 P26447 1/20 0.33
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
CHRM2 P08172 1/20 0.32
HTR1A P08908 1/20 0.32
ADRA2A P08913 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8184423 0.99 MALT1 (0.38) MALT1MAPK1HTTTDP1CRHBP
SCHEMBL8085346 0.85 ALDH1A1 (0.38) MALT1TDP1ALDH1A1PTPRCBCHE
SCHEMBL8088358 0.81 MALT1 (0.35) MALT1HTTNPY5RLMNAHTR1A
SCHEMBL8090669 0.80 MALT1 (0.36) MALT1NPY5RLMNAHTR1A
SCHEMBL9737279 0.79 CHRM2 (0.34) MALT1ALDH1A1PTPRCBCHEACHE
SCHEMBL8090555 0.78 TDP1 (0.37) MALT1MAPK1HTTTDP1CRHBP
SCHEMBL9734444 0.76 ALDH1A1 (0.36) MALT1TDP1ALDH1A1PTPRCBCHE
SCHEMBL8090151 0.76 ALDH1A1 (0.36) MALT1MAPK1HTTTDP1CRHBP
SCHEMBL9148573 0.76 ALDH1A1 (0.35) MALT1TDP1CRHBPCRHR2ALDH1A1
SCHEMBL9146508 0.76 CHRM2 (0.37) MALT1TDP1ALDH1A1PTPRCBCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6153627-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-11-28 US disclosed
US-6040308-A Chroman derivatives MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-03-21 US disclosed
US-5387587-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1995-02-07 US disclosed
US-5013853-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1991-05-07 US disclosed