SCHEMBL8090669

SCHEMBL8090669

CC1=C(n2ccccc2=O)c2cc(C#N)ccc2OC12CCCC2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 1/20 0.36
NPY5R Q15761 2/20 0.34
TRPV4 Q9HBA0 5/20 0.33
BACE1 P56817 1/20 0.33
HTR1A P08908 2/20 0.33
HTR2A P28223 1/20 0.33
ABCC9 O60706 3/20 0.32
ABCC8 Q09428 2/20 0.32
KCNJ11 Q14654 2/20 0.32
KCNJ8 Q15842 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
LMNA P02545 1/20 0.32
PGR P06401 2/20 0.32
PDE4A P27815 1/20 0.32
PDE4B Q07343 1/20 0.32
PDE4C Q08493 1/20 0.32
PDE4D Q08499 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8088358 0.99 MALT1 (0.35) MALT1NPY5RTRPV4BACE1HTR1A
SCHEMBL7267575 0.85 ABCC9 (0.37) MALT1HTR1AABCC9ABCC8KCNJ11
SCHEMBL8184423 0.80 MALT1 (0.38) MALT1NPY5RHTR1A
SCHEMBL8090463 0.80 MALT1 (0.37) MALT1NPY5RHTR1ALMNA
SCHEMBL9735328 0.79 MAOB (0.33) MALT1HTR1AABCC9PDE4APDE4B
SCHEMBL8084380 0.77 OPRD1 (0.39) MALT1BACE1HTR1AHTR2AABCC9
SCHEMBL8085327 0.76 MAOB (0.37) MALT1HTR1AABCC9ABCC8KCNJ11
SCHEMBL8084291 0.76 OPRD1 (0.39) MALT1BACE1HTR1AHTR2AABCC9
SCHEMBL9374251 0.76 BACE1 (0.36) MALT1NPY5RBACE1HTR1AHTR2A
SCHEMBL8090132 0.76 OPRD1 (0.39) MALT1BACE1HTR1AHTR2AABCC9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6153627-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-11-28 US disclosed
US-6040308-A Chroman derivatives MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-03-21 US disclosed
US-5387587-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1995-02-07 US disclosed
US-5013853-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1991-05-07 US disclosed