Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | SGK1 | O00141 | 6/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.37 |
| ▸ | MTOR | P42345 | 5/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8100133 | 0.93 | NAMPT (0.41) | NAMPTPIK3CAMTORPIK3CDHDAC3 | |
| SCHEMBL8100136 | 0.92 | NAMPT (0.41) | NAMPTPIK3CAMTORPIK3CDCA12 | |
| SCHEMBL8095173 | 0.91 | NAMPT (0.39) | NAMPTSGK1PIK3CAMTORPIK3CD | |
| SCHEMBL8090705 | 0.87 | NAMPT (0.40) | NAMPTPIK3CAMTORPIK3CDCA12 | |
| SCHEMBL8082685 | 0.87 | IDO1 (0.40) | SGK1PIK3CAMTORHDAC3PIK3CG | |
| SCHEMBL8090837 | 0.86 | MTOR (0.38) | NAMPTPIK3CAMTORPIK3CDCA12 | |
| SCHEMBL8104327 | 0.85 | NAMPT (0.39) | NAMPTPIK3CAMTORPIK3CDCA12 | |
| SCHEMBL8091717 | 0.84 | CA2 (0.40) | NAMPTPIK3CAMTORPIK3CDCA12 | |
| SCHEMBL8091538 | 0.84 | PIK3CD (0.43) | PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL8084009 | 0.83 | PIK3CD (0.42) | PIK3CAMTORPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |