Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 7/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095173 | 0.91 | NAMPT (0.39) | NAMPTPIK3CAPIK3CDMTORCA12 | |
| SCHEMBL8100136 | 0.90 | NAMPT (0.41) | NAMPTPIK3CAPIK3CDMTORCA12 | |
| SCHEMBL8099251 | 0.89 | NAMPT (0.38) | NAMPTPIK3CAPIK3CDMTORITGB3 | |
| SCHEMBL8091717 | 0.88 | CA2 (0.40) | NAMPTPIK3CAPIK3CDMTORCA12 | |
| SCHEMBL8099632 | 0.86 | CA1 (0.42) | NAMPTPIK3CAPIK3CDMTORCA12 | |
| SCHEMBL8091710 | 0.86 | PIK3CD (0.36) | NAMPTPIK3CAPIK3CDMTORCA12 | |
| SCHEMBL8091538 | 0.86 | PIK3CD (0.43) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8091143 | 0.86 | KIF11 (0.36) | NAMPTPIK3CAPIK3CD | |
| SCHEMBL8084009 | 0.85 | PIK3CD (0.42) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8090580 | 0.85 | NAMPT (0.39) | NAMPTPIK3CAPIK3CDMTORCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |