Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095173 | 0.91 | NAMPT (0.39) | MTORPIK3CAPIK3CDHTR3ACA12 | |
| SCHEMBL8097253 | 0.89 | PIK3CD (0.36) | MTORPIK3CAPIK3CDROCK2ROCK1 | |
| SCHEMBL8091717 | 0.88 | CA2 (0.40) | MTORPIK3CAPIK3CDCA12CA1 | |
| SCHEMBL8090705 | 0.87 | NAMPT (0.40) | MTORPIK3CAPIK3CDCA12CA1 | |
| SCHEMBL8100133 | 0.86 | NAMPT (0.41) | MTORPIK3CAPIK3CDCA12CA1 | |
| SCHEMBL8090580 | 0.86 | NAMPT (0.39) | MTORPIK3CAPIK3CDCA12CA1 | |
| SCHEMBL8090834 | 0.86 | KIF11 (0.35) | PIK3CDCA1CA2MAPT | |
| SCHEMBL8091538 | 0.86 | PIK3CD (0.43) | MTORPIK3CAPIK3CD | |
| SCHEMBL8084009 | 0.85 | PIK3CD (0.42) | MTORPIK3CAPIK3CD | |
| SCHEMBL8104327 | 0.85 | NAMPT (0.39) | MTORPIK3CAPIK3CDCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |