Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 6/20 | 0.38 |
| ▸ | DRD3 | P35462 | 6/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085352 | 0.89 | PDE4A (0.39) | EGLN2DRD2DRD3PDE4APDE4B | |
| SCHEMBL8088372 | 0.87 | PDE4A (0.39) | EGLN2DRD2DRD3PDE4APDE4B | |
| SCHEMBL8088696 | 0.85 | PDE4A (0.37) | EGLN2DRD2DRD3PDE4APDE4B | |
| SCHEMBL8085358 | 0.84 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8088667 | 0.83 | KMT2A (0.42) | — | |
| SCHEMBL9371959 | 0.83 | EGLN2 (0.39) | EGLN2DRD2DRD3ABCC9AR | |
| SCHEMBL8085132 | 0.83 | EGLN2 (0.39) | EGLN2DRD2DRD3ABCC9KDM4E | |
| SCHEMBL8084413 | 0.82 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9733497 | 0.81 | EGLN2 (0.38) | EGLN2DRD2DRD3AR | |
| SCHEMBL8077310 | 0.81 | PDE4A (0.37) | DRD2DRD3PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |