Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733537 | 0.89 | EGLN2 (0.33) | EGLN2DRD2DRD3ARPGR | |
| SCHEMBL9735233 | 0.86 | PGR (0.36) | EGLN2DRD2DRD3PGRHSP90AA1 | |
| SCHEMBL9733777 | 0.85 | EGLN2 (0.33) | EGLN2ARPPARGCNR2OTUD7B | |
| SCHEMBL9734810 | 0.84 | ABCC9 (0.32) | PGR | |
| SCHEMBL9733571 | 0.82 | POLB (0.33) | PGR | |
| SCHEMBL9733641 | 0.81 | OTUD7B (0.31) | OTUD7B | |
| SCHEMBL8090684 | 0.81 | EGLN2 (0.38) | EGLN2DRD2DRD3AR | |
| SCHEMBL9733591 | 0.80 | VCAM1 (0.37) | — | |
| SCHEMBL9733001 | 0.79 | OTUD7B (0.35) | DRD2DRD3ALDH1A1PGROTUD7B | |
| SCHEMBL9733746 | 0.78 | PGR (0.34) | PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |