Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 12/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084413 | 0.89 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8077016 | 0.89 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8085246 | 0.87 | ABCC9 (0.39) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8085300 | 0.86 | VCAM1 (0.39) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8084447 | 0.86 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8088878 | 0.85 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8088696 | 0.84 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8090684 | 0.84 | EGLN2 (0.38) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL7266950 | 0.81 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL8085129 | 0.80 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |