Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011792 | 0.95 | GAA (0.36) | CYP1A2ALDH1A1GAAGABRA1GABRG2 | |
| SCHEMBL7823416 | 0.93 | — | — | |
| SCHEMBL8017443 | 0.89 | FGFR1 (0.31) | CYP1A2SMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL8098049 | 0.84 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1LMNAGAAGABRA1 | |
| SCHEMBL8100190 | 0.84 | SMN1; SMN2 (0.33) | CYP1A2SMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL8020015 | 0.83 | P2RX7 (0.33) | ALDH1A1GAAMAPT | |
| SCHEMBL8013343 | 0.82 | GAA (0.38) | CYP1A2SMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL7835755 | 0.81 | ALDH1A1 (0.36) | SMN1; SMN2ALDH1A1LMNAGAAMEN1 | |
| SCHEMBL8099222 | 0.81 | GAA (0.38) | CYP1A2ALDH1A1GAAGABRA1GABRG2 | |
| SCHEMBL8098249 | 0.80 | CYP1A2 (0.33) | CYP1A2SMN1; SMN2ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100264-A | 5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their intermediates and medicaments containing them | RHONE-POULENC RORER, S.A. (FR) | 2000-08-08 | — | — | US | disclosed |
| US-5990108-A | USEFUL AS ANTAGONISTS OF THE ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) RECEPTOR, ALSO KNOWN AS THE QUISQUALATE RECEPTOR, AND AS ANTAGONISTS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR | RHONE POULENC RORER S.A. (FR) | 1999-11-23 | — | — | US | disclosed |