Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.31 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084249 | 0.83 | HIF1A (0.35) | MAPTKMT2AALPLALDH1A1L3MBTL1 | |
| SCHEMBL8182508 | 0.82 | ABCC9 (0.40) | LMNAABCC9 | |
| SCHEMBL8088761 | 0.78 | ABCC9 (0.38) | MAPTKMT2AALPLALDH1A1SMN1; SMN2 | |
| SCHEMBL9740284 | 0.76 | ALDH1A1 (0.33) | MAPTKMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8184316 | 0.75 | ALDH1A1 (0.40) | MAPTALDH1A1SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL8077034 | 0.74 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HTTL3MBTL1HIF1A | |
| SCHEMBL9143643 | 0.74 | ABCC9 (0.48) | ALPLLMNAABCC9HIF1A | |
| SCHEMBL7269364 | 0.74 | ABCC9 (0.48) | ALPLLMNAABCC9HIF1A | |
| SCHEMBL9143634 | 0.74 | ABCC9 (0.48) | ALPLLMNAABCC9HIF1A | |
| SCHEMBL9146484 | 0.73 | ALDH1A1 (0.34) | MAPTKMT2AALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |