Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740635 | 0.85 | IDO1 (0.35) | SMN1; SMN2 | |
| SCHEMBL8084249 | 0.85 | HIF1A (0.35) | ALDH1A1MAPTL3MBTL1AKR1B1KMT2A | |
| SCHEMBL9736924 | 0.83 | ABCC9 (0.40) | LMNAKMT2AABCC9MEN1 | |
| SCHEMBL9735486 | 0.83 | ALOX5 (0.36) | ALDH1A1MAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL9736167 | 0.81 | ABCC9 (0.37) | ALDH1A1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL8184316 | 0.81 | ALDH1A1 (0.40) | ALDH1A1MAPTSMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL9735385 | 0.80 | ABCC9 (0.39) | ALDH1A1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL8077034 | 0.80 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HTTL3MBTL1AKR1B1 | |
| SCHEMBL8090748 | 0.76 | MAPT (0.32) | ALDH1A1MAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL7269364 | 0.74 | ABCC9 (0.48) | LMNAHIF1AABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |