Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.63 |
| ▸ | HTR7 | P34969 | 1/20 | 0.61 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.59 |
| ▸ | HTR3B | O95264 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.59 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.59 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13979786 | 0.86 | HTR6 (0.65) | HTR6HTR7HTR3EHTR3BHTR3A | |
| SCHEMBL6187693 | 0.84 | HTR6 (0.58) | HTR6HTR7HTR4 | |
| SCHEMBL31588161 | 0.83 | HTR6 (0.71) | HTR6HTR7HTR4 | |
| SCHEMBL4659535 | 0.83 | HTR6 (0.58) | HTR6HTR7HTR4HTR3EHTR3B | |
| SCHEMBL4659557 | 0.83 | HTR6 (0.62) | HTR6HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4658417 | 0.82 | HTR3E (0.69) | HTR6HTR7HTR3EHTR3BHTR3A | |
| SCHEMBL28027580 | 0.81 | ALDH1A1 (0.58) | HTR6HTR7HTR4HTR3EHTR3B | |
| SCHEMBL4658341 | 0.81 | HTR6 (0.72) | HTR6HTR7HTR3EHTR3BHTR3A | |
| SCHEMBL7160310 | 0.81 | HTR6 (0.69) | HTR6HTR7HTR4 | |
| SCHEMBL32672532 | 0.81 | HTR6 (0.59) | HTR6HTR7HTR4HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049679-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-08 | — | — | EP | claimed |
| WO-1999037623-A2 | SULPHONAMIDE DERIVATIVES FOR TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | claimed |