Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.40 |
| ▸ | MTOR | P42345 | 9/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 3/20 | 0.37 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.37 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090948 | 0.92 | CA12 (0.41) | PIK3CAMTORCA12CA1CA2 | |
| SCHEMBL8084016 | 0.92 | CA12 (0.41) | PIK3CAMTORCA12CA1CA2 | |
| SCHEMBL8092374 | 0.91 | PIK3CD (0.39) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8084833 | 0.91 | CA12 (0.43) | CA12CA1CA2CA9 | |
| SCHEMBL8092188 | 0.88 | PIK3CA (0.45) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8097463 | 0.88 | PIK3CA (0.39) | PIK3CAMTORPIK3CGPIK3CDATR | |
| SCHEMBL8090316 | 0.86 | KDR (0.37) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8099405 | 0.86 | EPHX1 (0.42) | PIK3CAMTORCA12CA1CA2 | |
| SCHEMBL8092236 | 0.86 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPIK3CDCA12 | |
| SCHEMBL8098812 | 0.85 | NPC1 (0.43) | CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |