Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.39 |
| ▸ | MTOR | P42345 | 6/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091293 | 0.93 | MAPT (0.42) | PIK3CAMTORPIK3CGATRKDM4E | |
| SCHEMBL8091191 | 0.88 | PIK3CA (0.40) | PIK3CAMTORPIK3CGATRPIK3CD | |
| SCHEMBL8092236 | 0.87 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8090868 | 0.84 | MTOR (0.38) | PIK3CAMTORPIK3CGKDM4EMAPT | |
| SCHEMBL8084155 | 0.84 | MAPT (0.39) | PIK3CAMTORPIK3CGATRKDM4E | |
| SCHEMBL8083200 | 0.83 | ALDH1A1 (0.43) | PIK3CAMTORPIK3CGPIK3R1CSF1R | |
| SCHEMBL8090246 | 0.83 | PIK3CA (0.42) | PIK3CAMTORPIK3CGKDM4EMAPT | |
| SCHEMBL8092374 | 0.83 | PIK3CD (0.39) | PIK3CAMTORPIK3CGATRKDM4E | |
| SCHEMBL8097966 | 0.82 | KIF11 (0.37) | PIK3CAMTORPIK3CGKDM4EMAPT | |
| SCHEMBL8090158 | 0.81 | MTOR (0.46) | PIK3CAMTORPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |