Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090948 | 0.98 | CA12 (0.41) | CA12CA1CA2CA9EPHX2 | |
| SCHEMBL8084833 | 0.95 | CA12 (0.43) | CA12CA1CA2CA9EPHX2 | |
| SCHEMBL8091191 | 0.92 | PIK3CA (0.40) | CA12CA1CA2CA9PIK3CA | |
| SCHEMBL8092374 | 0.89 | PIK3CD (0.39) | CA12CA1CA2CA9PIK3CA | |
| SCHEMBL8090316 | 0.89 | KDR (0.37) | CA12CA1CA2CA9EPHX2 | |
| SCHEMBL8099405 | 0.88 | EPHX1 (0.42) | CA12CA1CA2CA9EPHX2 | |
| SCHEMBL8097518 | 0.88 | KDR (0.38) | CA12CA1CA2CA9EPHX2 | |
| SCHEMBL8098812 | 0.88 | NPC1 (0.43) | CA12CA1CA2CA9EPHX2 | |
| SCHEMBL8084166 | 0.86 | ALDH1A1 (0.45) | CA12CA1CA2CA9SMN1; SMN2 | |
| SCHEMBL8096342 | 0.86 | PIK3CA (0.41) | PIK3CAMTORKDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |