SCHEMBL8091279

SCHEMBL8091279

CCC[CH]C(NCCCc1ccccc1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 13/20 0.50
KCNH2 Q12809 1/20 0.45
KDM4A O75164 1/20 0.45
LMNA P02545 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
TSHR P16473 1/20 0.44
CYP2C19 P33261 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
EPHX2 P34913 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9373860 0.96 SIGMAR1 (0.52) SIGMAR1LMNACYP1A2CYP3A4CYP2D6
SCHEMBL9374331 0.89 SIGMAR1 (0.49) SIGMAR1KCNH2MEN1KMT2A
SCHEMBL8976770 0.84 SIGMAR1 (0.43) SIGMAR1KCNH2LMNACYP1A2CYP3A4
SCHEMBL9158629 0.84 ALDH1A1 (0.48) LMNACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8096618 0.84 SIGMAR1 (0.53) SIGMAR1KCNH2MEN1KMT2A
SCHEMBL9150904 0.78 SIGMAR1 (0.49) SIGMAR1KCNH2KDM4ALMNACYP1A2
SCHEMBL8977015 0.78 CYP1A2 (0.46) SIGMAR1LMNACYP1A2CYP3A4CYP2D6
SCHEMBL7022052 0.73 SIGMAR1 (0.64) SIGMAR1KCNH2LMNACYP1A2CYP3A4
SCHEMBL8976810 0.73 SIGMAR1 (0.44) SIGMAR1KCNH2LMNACYP1A2CYP3A4
SCHEMBL15130899 0.73 SIGMAR1 (0.64) SIGMAR1KCNH2LMNACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed