Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 16/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9150904 | 0.89 | SIGMAR1 (0.49) | SIGMAR1KCNH2 | |
| SCHEMBL9373860 | 0.88 | SIGMAR1 (0.52) | SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL8091279 | 0.84 | SIGMAR1 (0.50) | SIGMAR1MEN1KMT2AKCNH2 | |
| SCHEMBL9374331 | 0.81 | SIGMAR1 (0.49) | SIGMAR1MEN1KMT2AKCNH2 | |
| SCHEMBL8976810 | 0.80 | SIGMAR1 (0.44) | SIGMAR1MEN1KMT2AKCNH2 | |
| SCHEMBL8099628 | 0.76 | EPHX2 (0.57) | SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL15131171 | 0.76 | SIGMAR1 (0.65) | SIGMAR1L3MBTL1MEN1KMT2AKCNH2 | |
| SCHEMBL8091460 | 0.75 | CYP3A4 (0.45) | MEN1KMT2AKCNH2 | |
| SCHEMBL12312527 | 0.73 | SIGMAR1 (0.71) | SIGMAR1L3MBTL1KMT2A | |
| SCHEMBL8092975 | 0.73 | SIGMAR1 (0.62) | SIGMAR1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |