Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8091361 | 1.00 | KDM1A (0.42) | KDM1AMITFHSP90AA1RAB9ALMNA | |
| Fumaric Acid SCHEMBL27554094 | 1.00 | KDM1A (0.42) | KDM1AMITFHSP90AA1RAB9ALMNA | |
| SCHEMBL6951259 | 0.88 | KDM1A (0.51) | KDM1AADRA2ACYP19A1CYP11B1CYP11B2 | |
| Fumaric Acid SCHEMBL8091878 | 0.78 | ADRA2A (0.46) | MITFHSP90AA1RAB9ALMNABLM | |
| Fumaric Acid SCHEMBL8091870 | 0.78 | ADRA2A (0.46) | MITFHSP90AA1RAB9ALMNABLM | |
| Fumaric Acid SCHEMBL8092398 | 0.78 | ADRA2A (0.46) | MITFHSP90AA1RAB9ALMNABLM | |
| Fumaric Acid SCHEMBL8085005 | 0.78 | ADRA2A (0.46) | MITFHSP90AA1RAB9ALMNABLM | |
| Fumaric Acid SCHEMBL8085007 | 0.78 | ADRA2A (0.46) | MITFHSP90AA1RAB9ALMNABLM | |
| Fumaric Acid SCHEMBL8092403 | 0.78 | ADRA2A (0.46) | MITFHSP90AA1RAB9ALMNABLM | |
| Fumaric Acid SCHEMBL8097779 | 0.71 | ACHE (0.39) | LMNABLMADRA2ANPSR1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |