Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ACP1 | P24666 | 2/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 2/20 | 0.48 |
| ▸ | CASR | P41180 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6464498 | 0.89 | ACP1 (0.61) | SMN1; SMN2ACP1METCA1CA2 | |
| SCHEMBL6469561 | 0.88 | CNR1 (0.50) | CNR1NPC1RAB9AALDH1A1MET | |
| SCHEMBL6463105 | 0.87 | CA1 (0.57) | ACP1METCA1CA2CA12 | |
| SCHEMBL8094923 | 0.86 | CNR1 (0.55) | CNR1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6468349 | 0.84 | PGR (0.62) | SMN1; SMN2METCA1CA2CA12 | |
| SCHEMBL6467730 | 0.82 | ACP1 (0.51) | NPC1RAB9AALDH1A1ACP1MET | |
| SCHEMBL6466509 | 0.82 | MET (0.61) | NPC1RAB9ASMN1; SMN2ALDH1A1MET | |
| SCHEMBL15145832 | 0.81 | ALDH1A1 (0.56) | CNR1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29400026 | 0.81 | NAMPT (0.58) | ALDH1A1MEN1KMT2A | |
| SCHEMBL23747462 | 0.80 | NAMPT (0.73) | CNR1NPC1RAB9ASMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0467621-B1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | LILLY CO ELI (US) | 1994-06-15 | — | — | EP | claimed |
| EP-0467621-A1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | claimed |
| US-6147115-A | SULFONYLUREIDO-4-HALOBENZENE DERIVATIVES; ANTICARCINOGENIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0467621-B1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | LILLY CO ELI (US) | 1994-06-15 | — | — | EP | disclosed |
| US-5216026-A | Administering to the mammal N-1-butanesulfonamide derivatives and salts | ELI LILLY AND COMPANY (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0467621-A1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |