SCHEMBL8091535

SCHEMBL8091535

CCN(CC)CCN(CC)C(=O)c1ccc(C(C)C)c(N)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 5/20 0.53
HSP90AB1 P08238 5/20 0.53
TSHR P16473 3/20 0.42
HPGD P15428 7/20 0.40
CYP1A2 P05177 2/20 0.39
CYP2D6 P10635 2/20 0.39
MAOA P21397 2/20 0.39
CYP2C19 P33261 2/20 0.39
HRH3 Q9Y5N1 2/20 0.39
CYP3A4 P08684 1/20 0.39
SCN1A P35498 1/20 0.39
KCNH2 Q12809 1/20 0.39
SCN2A Q99250 1/20 0.39
SIGMAR1 Q99720 1/20 0.39
SCN3A Q9NY46 1/20 0.39
TLR9 Q9NR96 1/20 0.39
TLR8 Q9NR97 1/20 0.39
TLR7 Q9NYK1 1/20 0.39
LMNA P02545 3/20 0.39
MEN1 O00255 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8090021 0.80 PDK1 (0.53) HSP90AA1HSP90AB1TSHRHPGDSMN1; SMN2
SCHEMBL8095271 0.76 HSP90AA1 (0.44) HSP90AA1HSP90AB1TSHRHPGDCYP1A2
SCHEMBL13236606 0.72 HPGD (0.49) HSP90AA1HSP90AB1TSHRHPGDLMNA
SCHEMBL4481559 0.72 LMNA (0.58) TSHRHPGDCYP1A2CYP2D6MAOA
SCHEMBL2952990 0.72 HSP90AA1 (0.57) HSP90AA1HSP90AB1TSHRHPGDCYP1A2
SCHEMBL31621299 0.72 HSP90AA1 (0.57) HSP90AA1HSP90AB1TSHRHPGDCYP1A2
SCHEMBL24370814 0.72 HSP90AA1 (0.66) HSP90AA1HSP90AB1TSHRHPGDCYP1A2
SCHEMBL16248225 0.72 HSP90AA1 (0.66) HSP90AA1HSP90AB1TSHRHPGDCYP1A2
SCHEMBL7453684 0.70 TERT (0.61) CYP2D6MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL7575487 0.70 ACE2 (0.56) HPGDCYP1A2LMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0807628-B1 Aromatic compound and pharmaceutical composition KUREHA CHEMICAL IND CO LTD (JP) 2000-12-20 EP disclosed
EP-0807628-A1 Aromatic compound and pharmaceutical composition Kureha Chemical Industry Co., Ltd. (JP) 1997-11-19 EP disclosed