Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091401 | 0.89 | PTGS1 (0.60) | ALDH1A1PTGS1PTGS2CYP2C9VCAM1 | |
| SCHEMBL8091369 | 0.85 | ALDH1A1 (0.50) | ALDH1A1PTGS1PTGS2CYP2C9VCAM1 | |
| SCHEMBL8588734 | 0.84 | PTGS1 (0.47) | ALDH1A1PTGS1PTGS2SMN1; SMN2GLA | |
| SCHEMBL8104912 | 0.78 | PTGS1 (0.57) | ALDH1A1PTGS1PTGS2SMN1; SMN2CYP2C9 | |
| SCHEMBL8524909 | 0.78 | PTGS1 (0.54) | ALDH1A1PTGS1PTGS2SMN1; SMN2GLA | |
| SCHEMBL8480176 | 0.76 | PTGS1 (0.60) | ALDH1A1PTGS1PTGS2CYP2C9TSHR | |
| SCHEMBL8092102 | 0.76 | PTGS1 (0.60) | ALDH1A1PTGS1PTGS2CYP2C9LMNA | |
| SCHEMBL8107816 | 0.76 | PTGS1 (0.52) | PTGS1PTGS2SMN1; SMN2GLAVCAM1 | |
| SCHEMBL8091464 | 0.76 | PTGS2 (0.62) | ALDH1A1PTGS1PTGS2SMN1; SMN2GLA | |
| SCHEMBL8481953 | 0.75 | PTGS1 (0.59) | ALDH1A1PTGS1PTGS2CYP2C9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |
| EP-0848703-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | Nycomed Austria GmbH (AT) | 1998-06-24 | — | — | EP | disclosed |
| WO-1997003953-A1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 1997-02-06 | — | — | WO | disclosed |