Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.35 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | AKT2 | P31751 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098135 | 0.96 | MTOR (0.39) | MTORPIK3CAPIK3CGPIK3CDATR | |
| SCHEMBL8092294 | 0.90 | ROCK2 (0.39) | MTORPIK3CAPIK3CDATRNAMPT | |
| SCHEMBL8092270 | 0.90 | NPC1 (0.43) | MTORPIK3CAATRKMT2APIK3R1 | |
| SCHEMBL8096681 | 0.90 | ATR (0.40) | MTORPIK3CAATRNAMPTIGF1R | |
| SCHEMBL8091924 | 0.89 | NAMPT (0.39) | PIK3CAPIK3CDATRNAMPT | |
| SCHEMBL8098769 | 0.88 | NAMPT (0.39) | PIK3CDATRNAMPT | |
| SCHEMBL8098805 | 0.87 | PIK3CD (0.36) | PIK3CAPIK3CDATRNAMPTIGF1R | |
| SCHEMBL8091129 | 0.87 | KDR (0.40) | ATR | |
| SCHEMBL8090246 | 0.87 | PIK3CA (0.42) | MTORPIK3CAPIK3CGPIK3CDNAMPT | |
| SCHEMBL8097714 | 0.86 | NAMPT (0.39) | PIK3CAPIK3CDATRNAMPTIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |