Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098769 | 0.92 | NAMPT (0.39) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL8099965 | 0.88 | NAMPT (0.39) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL8091924 | 0.88 | NAMPT (0.39) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL8096070 | 0.86 | MTOR (0.40) | NAMPTPIK3CDATRKMT2AIGF1R | |
| SCHEMBL8091502 | 0.86 | NAMPT (0.39) | NAMPTPIK3CDMAPTPIK3CA | |
| SCHEMBL8092294 | 0.86 | ROCK2 (0.39) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL8092270 | 0.85 | NPC1 (0.43) | NPC1ATRRAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL8098808 | 0.85 | NAMPT (0.39) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL8083970 | 0.85 | NAMPT (0.39) | NAMPTCA12CA1CA2CA9 | |
| SCHEMBL8090849 | 0.85 | NAMPT (0.39) | NAMPTCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |