Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13113281 | 0.84 | FAAH (0.41) | FAAHPTPN1CES2 | |
| SCHEMBL3220018 | 0.84 | PTPN1 (0.43) | FAAHPTPN1CES2 | |
| SCHEMBL19630951 | 0.83 | HPGD (0.35) | EPHX1PTPN1 | |
| SCHEMBL13671233 | 0.83 | FAAH (0.45) | FAAHPTPN1CES2 | |
| SCHEMBL4668386 | 0.83 | FAAH (0.45) | FAAHPTPN1CES2 | |
| SCHEMBL4666760 | 0.83 | FAAH (0.45) | FAAHPTPN1CES2 | |
| SCHEMBL4602875 | 0.83 | FAAH (0.40) | FAAHPTPN1CES2 | |
| SCHEMBL4296201 | 0.83 | FAAH (0.45) | FAAHPTPN1CES2 | |
| SCHEMBL1347954 | 0.83 | RELA (0.41) | FAAH | |
| SCHEMBL11500930 | 0.83 | FAAH (0.40) | FAAHPTPN1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147115-A | SULFONYLUREIDO-4-HALOBENZENE DERIVATIVES; ANTICARCINOGENIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0550157-B1 | Antitumor compositions and methods of treatment | LILLY CO ELI (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5354778-A | N-Phenyl-N'-substituted phenylsulfonylureas | ELI LILLY AND COMPANY (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0467621-B1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | LILLY CO ELI (US) | 1994-06-15 | — | — | EP | disclosed |
| US-5234955-A | N-phenyl-N*-substituted phenylsulfonylureas | ELI LILLY AND COMPANY (US) | 1993-08-10 | — | — | US | disclosed |
| EP-0550157-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-07-07 | — | — | EP | disclosed |
| US-5216026-A | Administering to the mammal N-1-butanesulfonamide derivatives and salts | ELI LILLY AND COMPANY (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0467621-A1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |