SCHEMBL8091957

SCHEMBL8091957

O=c1nc(-c2ccc(S(=O)(=O)O)cc2)c2c(=O)nc(-c3ccc(S(=O)(=O)O)cc3)c1=2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.43
ALDH1A1 P00352 6/20 0.42
TSHR P16473 4/20 0.42
NT5E P21589 1/20 0.42
ENPP2 Q13822 1/20 0.41
ADORA2B P29275 8/20 0.40
ADORA2A P29274 6/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
KDM4E B2RXH2 5/20 0.38
GLA P06280 3/20 0.38
HPGD P15428 3/20 0.38
HSD17B10 Q99714 3/20 0.38
ADORA3 P0DMS8 2/20 0.38
CYP2C19 P33261 2/20 0.38
NFKB1 P19838 1/20 0.38
ADORA1 P30542 1/20 0.38
TDP1 Q9NUW8 2/20 0.38
CYP2D6 P10635 2/20 0.36
POLB P06746 1/20 0.36
MAPT P10636 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9833339 0.93 TSHR (0.48) LMNATSHRSMN1; SMN2TDP1CYP2D6
SCHEMBL9835102 0.84 TDP1 (0.43) ALDH1A1HSD17B10TDP1
SCHEMBL525918 0.73 LMNA (0.65) LMNAALDH1A1TSHRNT5EENPP2
SCHEMBL3171676 0.73 LMNA (0.65) LMNAALDH1A1TSHRNT5EENPP2
SCHEMBL29990536 0.73 LMNA (0.65) LMNAALDH1A1TSHRNT5EENPP2
SCHEMBL447639 0.73 LMNA (0.65) LMNAALDH1A1TSHRNT5EENPP2
SCHEMBL115647 0.73 LMNA (0.47) LMNAALDH1A1TSHRADORA2AKDM4E
SCHEMBL9302668 0.71 LMNA (0.62) LMNAALDH1A1TSHRNT5EENPP2
Potassium SCHEMBL30064005 0.71 LMNA (0.62) LMNAALDH1A1TSHRNT5EENPP2
SCHEMBL9302694 0.71 LMNA (0.62) LMNAALDH1A1TSHRNT5EENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0656402-B1 Pigment compositions based on diketopyrrolopyrrols and an aminoalkyl acrylic resin CIBA SC HOLDING AG (CH) 2000-12-20 EP disclosed
US-5685901-A COLORFASTNESS; ENHANCED RHEOLOGY, SHELF LIFE CIBA-GEIGY CORPORATION (US) 1997-11-11 US disclosed
EP-0656402-A2 Pigment compositions based on diketopyrrolopyrrols and an aminoalkyl acrylic resin CIBA-GEIGY AG (CH) 1995-06-07 EP disclosed
EP-0224445-B1 PYRROLO-PYRROLE PIGMENT PREPARATIONS, THEIR PREPARATION PROCESS AND THEIR USE CIBA-GEIGY AG (CH) 1991-09-04 EP disclosed
US-4914211-A MIXTURE OF PYRROLOPYRROLES; COLORING HIGH MOLECULAR WEIGHT ORGANIC MATERIAL CIBA-GEIGY CORPORATION (US) 1990-04-03 US disclosed
US-4791204-A FOR COLORING POLYMERS CIBA-GEIGY CORPORATION (US) 1988-12-13 US disclosed