Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 9/20 | 0.40 |
| ▸ | CA1 | P00915 | 7/20 | 0.40 |
| ▸ | CA9 | Q16790 | 7/20 | 0.40 |
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575696 | 0.89 | PTGS1 (0.56) | PTGS2PTGS1CCR2CA2CA1 | |
| SCHEMBL8479236 | 0.88 | PTGS1 (0.44) | PTGS2PTGS1CCR2CA2CA1 | |
| SCHEMBL8099531 | 0.88 | CA1 (0.41) | PTGS2CA2CA1CA9CA12 | |
| SCHEMBL8098762 | 0.86 | PTGS1 (0.45) | PTGS2PTGS1CCR2CA2CA1 | |
| SCHEMBL8100934 | 0.84 | CA2 (0.44) | PTGS2PTGS1CCR2CA2CA1 | |
| SCHEMBL8091883 | 0.83 | PTGS1 (0.44) | PTGS2PTGS1CA2CA1CA9 | |
| SCHEMBL8107618 | 0.81 | NR3C1 (0.42) | PTGS2PTGS1CA2CA1CA9 | |
| SCHEMBL8101100 | 0.80 | CA2 (0.44) | PTGS2PTGS1CA2CA1CA9 | |
| SCHEMBL8101110 | 0.80 | CA2 (0.44) | PTGS2PTGS1CA2CA1CA9 | |
| SCHEMBL8098886 | 0.78 | CA2 (0.46) | CA2CA1CA9CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |
| US-6004948-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | NYCOMED AUSTRIA GMBH (AT) | 1999-12-21 | — | — | US | disclosed |