Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1193527 | 0.86 | HDAC1 (0.66) | HPGDPOLBHTTNR1H4HDAC3 | |
| SCHEMBL28898473 | 0.85 | L3MBTL1 (0.55) | HPGDPOLBNR1H4HDAC3HDAC4 | |
| SCHEMBL23471096 | 0.83 | POLB (0.58) | HPGDPOLBHTTNR1H4HDAC2 | |
| SCHEMBL3017701 | 0.81 | HPGD (0.57) | HPGDPOLBHTTHDAC3HDAC4 | |
| Ethylene Glycol SCHEMBL7527989 | 0.81 | KDM4E (0.59) | HPGDPOLBNR1H4KDM4EALDH1A1 | |
| SCHEMBL3453839 | 0.80 | HPGD (0.55) | HPGDPOLBHTTHDAC3HDAC4 | |
| Terephthalic Acid SCHEMBL7993200 | 0.79 | KDM4E (0.57) | HPGDPOLBNR1H4KDM4EALDH1A1 | |
| SCHEMBL620074 | 0.79 | POLB (0.66) | HPGDPOLBHTTHDAC4HDAC6 | |
| SCHEMBL28810616 | 0.78 | NR1H4 (0.53) | NR1H4KDM4EALDH1A1MAPTPTPN11 | |
| 1,3-Propanediol SCHEMBL3356738 | 0.77 | KDM4E (0.55) | HPGDPOLBNR1H4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810206-B1 | Substituted 2-naphthoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them | HOECHST AG (DE) | 2000-12-27 | — | — | EP | disclosed |
| US-6087304-A | ANTIARRHYTHMIC PHARMACEUTICALS HAVING A CARDIOPROTECTIVE COMPONENT FOR INFARCT PROPHYLAXIS AND INFARCT TREATMENT AND FOR THE TREATMENT OF ANGINA PECTORIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-07-11 | — | — | US | disclosed |
| CN-1167759-A | Substd. 2-naphthoyl guanidines, their preparing method, use and drug contg. them | HOECHST AG (DE) | 1997-12-17 | — | — | CN | disclosed |
| EP-0810206-A1 | Substituted 2-naphtoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-03 | — | — | EP | disclosed |