Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | NAAA | Q02083 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.51 |
| ▸ | CCR1 | P32246 | 3/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091484 | 0.94 | DRD2 (0.55) | GRM5NAAAMCHR1CCR1MEN1 | |
| SCHEMBL8091568 | 0.94 | MEN1 (0.54) | CCR1MEN1ALDH1A1LMNAHPGD | |
| SCHEMBL8084591 | 0.91 | MCHR1 (0.48) | GRM5NAAAMCHR1CCR1MEN1 | |
| SCHEMBL3878560 | 0.90 | CCR1 (0.58) | GRM5CCR1MEN1KMT2A | |
| SCHEMBL3869863 | 0.88 | MCHR1 (0.54) | GRM5MCHR1CCR1MEN1ALDH1A1 | |
| SCHEMBL3870960 | 0.86 | CCR1 (0.50) | GRM5MCHR1CCR1MEN1ALDH1A1 | |
| SCHEMBL3867771 | 0.86 | CCR1 (0.50) | GRM5MCHR1CCR1MEN1ALDH1A1 | |
| SCHEMBL3994513 | 0.84 | MAPT (0.53) | MCHR1MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL8092824 | 0.84 | SIGMAR1 (0.59) | MEN1ALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL13646635 | 0.83 | CCR1 (0.47) | GRM5MCHR1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |