Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092580 | 0.91 | GRM5 (0.53) | MCHR1GRM5NAAACCR1KMT2A | |
| SCHEMBL8091484 | 0.85 | DRD2 (0.55) | MCHR1GRM5NAAACCR1KMT2A | |
| SCHEMBL8091568 | 0.85 | MEN1 (0.54) | CCR1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3878560 | 0.81 | CCR1 (0.58) | GRM5CCR1KMT2AMEN1CACNA1G | |
| SCHEMBL3869863 | 0.80 | MCHR1 (0.54) | MCHR1GRM5CCR1KMT2AMEN1 | |
| SCHEMBL8097197 | 0.80 | NAAA (0.55) | NAAACCR1KMT2AMEN1ALDH1A1 | |
| SCHEMBL3870960 | 0.78 | CCR1 (0.50) | MCHR1GRM5CCR1KMT2AMEN1 | |
| SCHEMBL3867771 | 0.78 | CCR1 (0.50) | MCHR1GRM5CCR1KMT2AMEN1 | |
| SCHEMBL3994513 | 0.76 | MAPT (0.53) | MCHR1KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL30616890 | 0.76 | MCHR1 (0.44) | MCHR1GRM5NAAACCR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |