SCHEMBL8092634

SCHEMBL8092634

Clc1nc2c(-c3ccccc3)cccc2s1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.51
RET P07949 1/20 0.41
FLT1 P17948 1/20 0.41
KDR P35968 1/20 0.41
MAPK14 Q16539 1/20 0.41
CYP2A6 P11509 1/20 0.41
ENPP1 P22413 2/20 0.40
LIMK1 P53667 1/20 0.40
LMNA P02545 4/20 0.40
PDE10A Q9Y233 1/20 0.40
LIPG Q9Y5X9 3/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C8 P10632 1/20 0.39
CYP2C9 P11712 1/20 0.39
DHODH Q02127 1/20 0.39
MAPT P10636 3/20 0.37
NPC1 O15118 2/20 0.37
CTRC Q99895 1/20 0.37
MEN1 O00255 2/20 0.37
GAA P10253 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4851511 0.81 ENPP1 (0.50) ALDH1A1ENPP1MAPTKDM4ETP53
SCHEMBL28215029 0.80 APP (0.45) ALDH1A1RETFLT1KDRMAPK14
SCHEMBL1806582 0.79 ALDH1A1 (0.56) ALDH1A1RETFLT1KDRMAPK14
SCHEMBL27845716 0.79 RET (0.41) ALDH1A1RETFLT1KDRMAPK14
SCHEMBL1772204 0.79 RET (0.41) ALDH1A1RETFLT1KDRMAPK14
SCHEMBL28819175 0.79 RET (0.41) ALDH1A1RETFLT1KDRMAPK14
SCHEMBL900791 0.79 ALOX5 (0.43) ALDH1A1RETFLT1KDRMAPK14
SCHEMBL16004771 0.79 RET (0.47) ALDH1A1RETFLT1KDRMAPK14
SCHEMBL27795722 0.78 ALDH1A1 (0.44) ALDH1A1LMNACYP2C9MAPTNPC1
SCHEMBL4457161 0.77 RET (0.40) ALDH1A1RETFLT1KDRMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103304507-B Green method for preparing heterocyclic compounds from nitriles UNIV WENZHOU 2015-02-25 CN disclosed
US-6150375-A INHIBITORS OF BOTH OF THE HUMAN 5AR ISOZYMES; BENIGN PROSTATE HYPERPLASIA, MALE PATTERN BALDNESS, ACNE VULGARIS, SEBORRHEA, ANDROGENIC ALOPECIA, HIRSUTISM AND PROSTATE CANCER; BLOCKS THE CONVERSION OF TESTOSTERONE TO 5-ALPHA-DIHYDROTESTOSTERONE ELI LILLY AND COMPANY (US) 2000-11-21 US disclosed
US-5670514-A BENZOQUINOLIN-3-ONE ELI LILLY AND COMPANY (US) 1997-09-23 US disclosed
US-5635197-A BENZO(F)QUINOLIN-3-ONES; ANTICARCINOGENIC AGENTS; BONE DISORDERS ELI LILLY AND COMPANY (US) 1997-06-03 US disclosed
US-5629007-A USING BENZOQUINOLIN-3-ONE DERIVATIVES ELI LILLY AND COMPANY (US) 1997-05-13 US disclosed
US-5622961-A PROSTATE CANCER, SKIN DISORDERS, BALDNESS ELI LILLY AND COMPANY (US) 1997-04-22 US disclosed
US-5622962-A PROSTATE CANCER, SKIN DISORDERS, BALDNESS ELI LILLY AND COMPANY (US) 1997-04-22 US disclosed
CN-1138458-A Treatment and prevention of prostatic cancer LILLY CO ELI (US) 1996-12-25 CN disclosed
US-5578724-A INHIBITORS OF 5-ALPHA-REDUCTASE ELI LILLY AND COMPANY (US) 1996-11-26 US disclosed
WO-1996035422-A1 METHODS FOR INHIBITING BONE LOSS ELI LILLY AND COMPANY (US) 1996-11-14 WO disclosed
EP-0742010-A2 Benzoquinolin-3-ones to inhibit bone loss ELI LILLY AND COMPANY (US) 1996-11-13 EP disclosed
EP-0733365-A2 Use of benzoquinolin-3-ones for the treatment and prevention of prostatic cancer ELI LILLY AND COMPANY (US) 1996-09-25 EP disclosed
US-5550134-A ADMINISTERING TO A MAMMAL FROM A SERIES OF BENZOQUINOLIN-3-ONE COMPOUNDS ELI LILLY AND COMPANY (US) 1996-08-27 US disclosed
US-5347008-A Thio(cyclo) alkanepolycarboxylic acids containing heterocyclic substituents CIBA-GEIGY CORPORATION (US) 1994-09-13 US disclosed
US-5152929-A Corrosion inhibitors for water systems CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed
EP-0129506-B1 HETEROCYCLICALLY SUBSTITUTED THIO(CYCLO)ALKANE POLYCARBOXYLIC ACIDS CIBA-GEIGY AG (CH) 1991-03-06 EP disclosed
EP-0129506-A2 Heterocyclically substituted thio(cyclo)alkane polycarboxylic acids CIBA-GEIGY AG (CH) 1984-12-27 EP disclosed