SCHEMBL1772204

SCHEMBL1772204

Sc1nc2c(-c3ccccc3)cccc2s1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RET P07949 1/20 0.41
FLT1 P17948 1/20 0.41
KDR P35968 1/20 0.41
MAPK14 Q16539 1/20 0.41
LIMK1 P53667 2/20 0.40
ENPP1 P22413 2/20 0.40
LIPG Q9Y5X9 3/20 0.37
F9 P00740 1/20 0.36
TNF P01375 1/20 0.35
MEN1 O00255 2/20 0.33
RAB9A P51151 2/20 0.33
KMT2A Q03164 2/20 0.33
DHODH Q02127 1/20 0.33
ALDH1A1 P00352 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
ALPL P05186 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11391805 0.81 RET (0.32) RETFLT1KDRMAPK14
SCHEMBL28215029 0.80 APP (0.45) RETFLT1KDRMAPK14LIMK1
SCHEMBL1806582 0.79 ALDH1A1 (0.56) RETFLT1KDRMAPK14LIMK1
SCHEMBL16004771 0.79 RET (0.47) RETFLT1KDRMAPK14LIMK1
SCHEMBL900791 0.79 ALOX5 (0.43) RETFLT1KDRMAPK14LIMK1
SCHEMBL28819175 0.79 RET (0.41) RETFLT1KDRMAPK14LIMK1
SCHEMBL8092634 0.79 ALDH1A1 (0.51) RETFLT1KDRMAPK14LIMK1
SCHEMBL27845716 0.79 RET (0.41) RETFLT1KDRMAPK14LIMK1
SCHEMBL1771056 0.77 FBP1 (0.50) RETFLT1KDRMAPK14LIMK1
SCHEMBL4460654 0.77 ENPP1 (0.42) RETFLT1KDRMAPK14LIMK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559587-B1 Agricultural or industrial tire with reinforced rubber composition GOODYEAR TIRE & RUBBER (US) 2008-08-20 EP claimed
US-20070187030-A1 Agricultural or industrial tire with reinforced rubber composition THE GOODYEAR TIRE & RUBBER COMPANY 2007-08-16 US claimed
EP-1559587-A2 Agricultural or industrial tire with reinforced rubber composition THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-08-03 EP claimed
US-20040182486-A1 Agricultural or industrial tire with reinforced rubber composition BERNARD CARLO (LU) 2004-09-23 US claimed
US-5283016-A Method for preparing photosensitive microcapsules THE MEAD CORPORATION (US) 1994-02-01 US claimed
US-3947459-A FROM ALKALI SALT OF MERCAPTOTHIAZOLES, AMINES AND BLEACH THE GOODYEAR TIRE & RUBBER COMPANY (US) 1976-03-30 US claimed
CN-114144410-A Polyarylurea derivatives and their use in the treatment of muscular diseases 阿纳格纳斯生物技术股份有限公司 2022-03-04 CN disclosed
EP-2325242-B1 Rubber composition for cap tread and studless tire SUMITOMO RUBBER IND (JP) 2013-07-10 EP disclosed
US-20120259038-A1 RUBBER COMPOSITION FOR CAP TREAD AND WINTER TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2012-10-11 US disclosed
EP-2325242-A1 Rubber composition for cap tread and studless tire Sumitomo Rubber Industries, Ltd. (JP) 2011-05-25 EP disclosed
US-20110112214-A1 RUBBER COMPOSITION FOR CAP TREAD AND STUDLESS TIRE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2011-05-12 US disclosed
EP-1559587-B1 Agricultural or industrial tire with reinforced rubber composition GOODYEAR TIRE & RUBBER (US) 2008-08-20 EP disclosed
US-20070187030-A1 Agricultural or industrial tire with reinforced rubber composition THE GOODYEAR TIRE & RUBBER COMPANY 2007-08-16 US disclosed
EP-0126030-A2 Process for the preparation of beta-(benzothiazolylthio) and beta-(benzimidazolylthio) carboxylic acids CIBA-GEIGY AG (CH) 1984-11-21 EP disclosed
EP-0042937-B1 ANTIFREEZE CONCENTRATE CONTAINING INHIBITORS TO PREVENT LOCALIZED CORROSION OF ALUMINUM AND SOLDER ALLOY BASF WYANDOTTE CORPORATION (US) 1984-10-10 EP disclosed
US-4452715-A PH MAINTAINED BY DECARBOXYLATION OF BICARBONATE OR CARBONATE IONS BASF WYANDOTTE CORPORATION (US) 1984-06-05 US disclosed
EP-0042937-A1 Antifreeze concentrate containing inhibitors to prevent localized corrosion of aluminum and solder alloy BASF WYANDOTTE CORPORATION (US) 1982-01-06 EP disclosed
US-4307236-A BY CATALYTIC OXIDATION OF 2-MERCAPTO THIAZOLES AKZONA INCORPORATED (US) 1981-12-22 US disclosed
US-4182873-A AMINATION OF MERCAPTO THIAZOLE OR DISULFIDE RHONE-POULENC S.A. (FR) 1980-01-08 US disclosed
US-3947459-A FROM ALKALI SALT OF MERCAPTOTHIAZOLES, AMINES AND BLEACH THE GOODYEAR TIRE & RUBBER COMPANY (US) 1976-03-30 US disclosed