Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19629705 | 0.88 | L3MBTL1 (0.53) | ALOX5RETFLT1KDRMAPK14 | |
| SCHEMBL901023 | 0.84 | ENPP1 (0.41) | ALOX5RETFLT1KDRMAPK14 | |
| SCHEMBL4846484 | 0.82 | TNF (0.47) | ALDH1A1ENPP1RAB9ANPC1HTT | |
| SCHEMBL28073818 | 0.82 | CYP2A6 (0.46) | ALDH1A1RAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL4846110 | 0.81 | ENPP1 (0.44) | ALDH1A1ENPP1NPC1 | |
| SCHEMBL26535837 | 0.81 | PIM3 (0.35) | ALOX5LIMK1ENPP1RAB9ANPC1 | |
| SCHEMBL28215029 | 0.80 | APP (0.45) | RETFLT1KDRMAPK14LIMK1 | |
| SCHEMBL20043278 | 0.79 | HSD17B10 (0.41) | ALOX5ALDH1A1RAB9ANPC1TLR8 | |
| SCHEMBL906903 | 0.79 | SMN1; SMN2 (0.50) | ALDH1A1RAB9ANPC1TLR8TLR7 | |
| SCHEMBL8092634 | 0.79 | ALDH1A1 (0.51) | RETFLT1KDRMAPK14LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103228643-B | As the benzoxazole derivative of histamine h 4 receptor part | BIOPROJET (FR) | 2015-11-25 | — | — | CN | claimed |
| CN-103228643-A | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET SOC CIV | 2013-07-31 | — | — | CN | claimed |
| EP-2491041-B1 | BIVALENT DIAZO BICYCLIC SMAC MIMETICS AND THE USES THEREOF | UNIV MICHIGAN REGENTS (US) | 2017-08-09 | — | — | EP | disclosed |
| CN-106349184-A | Preparation method of 2- (ortho-alkylaryl) benzothiazole series | 江西师范大学 | 2017-01-25 | — | — | CN | disclosed |
| CN-103228643-B | As the benzoxazole derivative of histamine h 4 receptor part | BIOPROJET (FR) | 2015-11-25 | — | — | CN | disclosed |
| US-9029357-B2 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2015-05-12 | — | — | US | disclosed |
| CN-103304507-B | Green method for preparing heterocyclic compounds from nitriles | UNIV WENZHOU | 2015-02-25 | — | — | CN | disclosed |
| US-20150004181-A1 | Benzazole Derivatives as Histamine H4 Receptor Ligands | BIOPROJET SOC CIV (FR) | 2015-01-01 | — | — | US | disclosed |
| US-8815927-B2 | Bivalent diazo bicyclic Smac mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-08-26 | — | — | US | disclosed |
| US-8802664-B2 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJECT (FR) | 2014-08-12 | — | — | US | disclosed |
| US-20130231329-A1 | Benzazole Derivatives as Histamine H4 Receptor Ligands | BIOPROJET (FR) | 2013-09-05 | — | — | US | disclosed |
| EP-2621916-A1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET (FR) | 2013-08-07 | — | — | EP | disclosed |
| CN-103228643-A | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET SOC CIV | 2013-07-31 | — | — | CN | disclosed |
| US-20120263675-A1 | BIVALENT DIAZO BICYCLIC SMAC | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-10-18 | — | — | US | disclosed |
| WO-2012041860-A1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET (FR) | 2012-04-05 | — | — | WO | disclosed |
| US-20090061141-A1 | Monomethine dye compound, optical information recording medium utilizing the compound and process for producing the same | TAIYO YUDEN CO., LTD. (JP) | 2009-03-05 | — | — | US | disclosed |
| US-20090061141-A1 | Monomethine dye compound, optical information recording medium utilizing the compound and process for producing the same | TAIYO YUDEN CO., LTD. (JP) | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150004181-A1 | Benzazole Derivatives as Histamine H4 Receptor Ligands | HRH4, HRH3, HRH2 | ALOX5 3343/4885RET 529/4885FLT1 1972/4885 |
| US-20090061141-A1 | Monomethine dye compound, optical information recording medium utilizing the compound and process for producing the same | KDM7A, CUTA, KMO | ALOX5 1099/4885RET 3708/4885FLT1 2019/4885 |
| US-20130231329-A1 | Benzazole Derivatives as Histamine H4 Receptor Ligands | HRH4, HRH3, HRH2 | ALOX5 2210/4885RET 642/4885FLT1 1308/4885 |
| US-20120263675-A1 | BIVALENT DIAZO BICYCLIC SMAC | BIRC2, BID, BIRC3 | ALOX5 4450/4885RET 2988/4885FLT1 3806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.