Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321077 | 0.88 | BCAT2 (0.59) | KMT2ABCAT2MAPTGAAALDH1A1 | |
| SCHEMBL300439 | 0.82 | AKR1C3 (0.55) | KMT2AAKR1C3MAPTGAAALDH1A1 | |
| SCHEMBL8962200 | 0.82 | CDC25B (0.68) | BCAT2AKR1C3ALDH1A1ATMTDP1 | |
| SCHEMBL29838630 | 0.82 | BCAT2 (0.62) | BCAT2ALDH1A1LMNA | |
| SCHEMBL34748 | 0.82 | BCAT2 (0.62) | BCAT2ALDH1A1LMNA | |
| SCHEMBL7022695 | 0.81 | AKR1C3 (0.53) | KMT2AAKR1C3MAPTGAAALDH1A1 | |
| SCHEMBL29496654 | 0.81 | AKR1C3 (0.53) | KMT2AAKR1C3MAPTGAAALDH1A1 | |
| SCHEMBL28340031 | 0.81 | AKR1C3 (0.53) | KMT2AAKR1C3MAPTGAAALDH1A1 | |
| SCHEMBL10854249 | 0.81 | CA2 (0.58) | KMT2AAKR1C3MAPTGAAALDH1A1 | |
| Water SCHEMBL27666388 | 0.81 | AKR1C3 (0.53) | KMT2AAKR1C3MAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058682-A1 | HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USES IN THERAPEUTICS | LABORATOIRES UPSA (FR) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999043664-A1 | HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USES IN THERAPEUTICS | LABORATOIRES UPSA (FR) | 1999-09-02 | — | — | WO | disclosed |
| CN-1215396-A | Diarylmethylidene furan derivatives, preparation method and therapeutic use thereof | UNION PHARMA SCIENT APPL (FR) | 1999-04-28 | — | — | CN | disclosed |