SCHEMBL8092768

SCHEMBL8092768

CC(=C(C(=O)N1CCOCC1)c1ccccc1)c1cccc(S(C)(=O)=O)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.49
RECQL P46063 1/20 0.49
ALDH1A1 P00352 3/20 0.45
AKR1C3 P42330 2/20 0.44
ALB P02768 1/20 0.43
TDP1 Q9NUW8 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
MAPK1 P28482 1/20 0.43
KMT2A Q03164 1/20 0.43
POLB P06746 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
LMNA P02545 1/20 0.42
GAA P10253 2/20 0.42
HSD17B10 Q99714 1/20 0.42
PIK3CD O00329 1/20 0.42
PIK3R2 O00459 1/20 0.42
PIK3CA P42336 1/20 0.42
PIK3CB P42338 1/20 0.42
PIK3CG P48736 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6326755 0.88 PTGS2 (0.51) TSHRAKR1C3TDP1RAB9AMAPK1
SCHEMBL12157463 0.80 TSHR (0.73) TSHRRECQLALDH1A1AKR1C3RAB9A
SCHEMBL6250250 0.78 ALDH1A1 (0.52) ALDH1A1AKR1C3SMN1; SMN2GAAHSD17B10
SCHEMBL6250244 0.78 ALDH1A1 (0.52) ALDH1A1AKR1C3SMN1; SMN2GAAHSD17B10
Methylphenylsulfone SCHEMBL13270292 0.74 AKR1C3 (0.58) TSHRRECQLALDH1A1AKR1C3RAB9A
Morpholine SCHEMBL9436743 0.69 MAPT (0.46) TSHRRECQLALDH1A1AKR1C3TDP1
SCHEMBL11711031 0.68 RAB9A (0.54) TSHRALDH1A1AKR1C3NPC1RAB9A
SCHEMBL8386522 0.68 PHGDH (0.70) TSHRALDH1A1AKR1C3NPC1RAB9A
SCHEMBL5264773 0.68 ALDH1A1 (0.59) ALDH1A1TDP1SMN1; SMN2GAAHSD17B10
SCHEMBL13800995 0.67 TSHR (0.65) TSHRRAB9AKMT2APOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882015-B1 DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC (CA) 2000-12-27 EP claimed
EP-0882015-A1 DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1998-12-09 EP claimed
US-5733909-A ANTIINFLAMMATORY AGENTS; ANALGESICS; ANTIPYRETIC AGENT MERCK FROSST CANADA, INC. (CA) 1998-03-31 US claimed
WO-1997028120-A1 DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1997-08-07 WO claimed
EP-0882015-B1 DIPHENYL STILBENES AS PRODRUGS TO COX-2 INHIBITORS MERCK FROSST CANADA INC (CA) 2000-12-27 EP disclosed