Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | FPR2 | P25090 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | FPR1 | P21462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21182827 | 0.90 | EPHX2 (0.53) | ALDH1A1FPR2KDM4ERAB9AEPHX1 | |
| SCHEMBL8381645 | 0.80 | RAB9A (0.75) | ALDH1A1KDM4ERAB9ACHEK1CCR2 | |
| SCHEMBL15087624 | 0.80 | RAB9A (0.75) | ALDH1A1KDM4ERAB9ACHEK1CCR2 | |
| SCHEMBL10593938 | 0.79 | ALDH1A1 (0.56) | ALDH1A1FPR2KDM4ERAB9ACHEK1 | |
| SCHEMBL8095765 | 0.78 | ALDH1A1 (0.52) | ALDH1A1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL319610 | 0.77 | CCR2 (0.68) | ALDH1A1KDM4ERAB9ACCR2NPC1 | |
| SCHEMBL3487757 | 0.77 | CCR2 (0.68) | ALDH1A1KDM4ERAB9ACCR2NPC1 | |
| SCHEMBL3241217 | 0.77 | CCR2 (0.68) | ALDH1A1KDM4ERAB9ACCR2NPC1 | |
| SCHEMBL23874550 | 0.76 | CRBN (0.66) | RAB9AEPHX1EPHX2SMN1; SMN2MEN1 | |
| SCHEMBL21182644 | 0.76 | FPR2 (0.57) | ALDH1A1FPR2RAB9AEPHX1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096885-A | EXHIBIT AGONIST ACTIVITY FOR CCK-A RECEPTORS THEREBY ENABLING THEM TO MODULATE THE HORMONES GASTRIN AND CHOLECYSTOKININ IN MAMMALS. | GLAXO WELLCOME INC. (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0785944-A1 | ACYL AMINO ACETAMIDE DERIVATIVES WITH AGONIST ACTIVITY FOR CCK-A RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011940-A1 | ACYL AMINO ACETAMIDE DERIVATIVES WITH AGONIST ACTIVITY FOR CCK-A RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-04-25 | — | — | WO | disclosed |