Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 11/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096151 | 0.91 | PTGS2 (0.49) | CNR1PTGS2PTGS1 | |
| SCHEMBL8086461 | 0.86 | CNR1 (0.61) | CNR1PTGS2CA12CA1CA2 | |
| SCHEMBL8093875 | 0.85 | CNR1 (0.64) | CNR1PTGS2CA12CA1CA2 | |
| SCHEMBL8101248 | 0.84 | CNR1 (0.47) | CNR1PTGS2CA12CA1CA2 | |
| SCHEMBL8094551 | 0.83 | CNR1 (0.49) | CNR1PTGS2CA12CA1CA2 | |
| SCHEMBL8086490 | 0.83 | ALDH1A1 (0.42) | CNR1PTGS2CA12CA1CA2 | |
| SCHEMBL8095797 | 0.82 | CNR1 (0.69) | CNR1PTGS2CA12CA1CA2 | |
| SCHEMBL8094678 | 0.81 | SQOR (0.53) | CNR1PTGS2CNR2 | |
| SCHEMBL8095521 | 0.81 | CNR1 (0.52) | CNR1PTGS2CA12CA1CA2 | |
| SCHEMBL8094547 | 0.81 | PTGS2 (0.60) | CNR1PTGS2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |