Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 6/20 | 0.43 |
| ▸ | PTAFR | P25105 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091559 | 0.96 | TDP1 (0.48) | TDP1L3MBTL1CYP2A6HRH1HRH4 | |
| SCHEMBL8083504 | 0.88 | TDP1 (0.43) | TDP1L3MBTL1CYP2A6HRH1HRH4 | |
| SCHEMBL5834366 | 0.82 | CYP11B1 (0.42) | TDP1L3MBTL1 | |
| SCHEMBL6567905 | 0.81 | HTR2A (0.41) | TDP1L3MBTL1 | |
| SCHEMBL7430378 | 0.81 | L3MBTL1 (0.38) | L3MBTL1 | |
| SCHEMBL8091400 | 0.78 | L3MBTL1 (0.44) | TDP1L3MBTL1 | |
| SCHEMBL8090038 | 0.78 | ABCB1 (0.39) | TDP1L3MBTL1 | |
| SCHEMBL2843094 | 0.77 | CYP2A6 (0.76) | TDP1L3MBTL1CYP2A6HRH1HRH4 | |
| SCHEMBL29485677 | 0.77 | CYP2A6 (0.76) | TDP1L3MBTL1CYP2A6HRH1HRH4 | |
| SCHEMBL19090372 | 0.75 | TDP1 (0.57) | TDP1L3MBTL1CYP2A6HRH1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124328-A | TREATING NERVE CELLS WITH A NEUROTROPHIC AGENT; PROMOTING REPAIR OF NEURONAL DAMAGE CAUSED BY DISEASE OR PHYSICAL TRAUMA | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-09-26 | — | — | US | disclosed |
| US-6037370-A | TREATING ALZHEIMER*S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, PARKINSON*S DISEASE, AND OTHER NERVOUS SYSTEM DISORDERS WITH PEPTIDE DERIVATIVES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-03-14 | — | — | US | disclosed |