Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091400 | 0.97 | L3MBTL1 (0.44) | SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL8090038 | 0.97 | ABCB1 (0.39) | HTR2AIDO1SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL8090053 | 0.94 | LTA4H (0.40) | HTR2ASIGMAR1L3MBTL1 | |
| SCHEMBL7434046 | 0.92 | TDP1 (0.51) | SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL8090170 | 0.89 | TDP1 (0.49) | SIGMAR1TDP1L3MBTL1 | |
| SCHEMBL8091379 | 0.88 | HTR2A (0.35) | HTR2AIDO1TDP1L3MBTL1 | |
| SCHEMBL8091559 | 0.87 | TDP1 (0.48) | TDP1L3MBTL1 | |
| SCHEMBL8091561 | 0.87 | PTGER1 (0.49) | — | |
| SCHEMBL7428315 | 0.86 | KDM4E (0.41) | TDP1 | |
| SCHEMBL8083513 | 0.86 | HPGD (0.41) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404325-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2004-04-07 | — | — | EP | disclosed |
| WO-2002096420-A2 | METHOD FOR TREATING NERVE INJURY CAUSED BY SURGERY | GUILFORD PHARMACEUTICALS INC. (US) | 2002-12-05 | — | — | WO | disclosed |
| EP-1127049-A1 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL Holdings, Inc. (US) | 2001-08-29 | — | — | EP | disclosed |
| US-6124328-A | TREATING NERVE CELLS WITH A NEUROTROPHIC AGENT; PROMOTING REPAIR OF NEURONAL DAMAGE CAUSED BY DISEASE OR PHYSICAL TRAUMA | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-09-26 | — | — | US | disclosed |
| WO-2000016603-A2 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL HOLDINGS, INC. (US) | 2000-03-30 | — | — | WO | disclosed |
| US-6037370-A | TREATING ALZHEIMER*S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, PARKINSON*S DISEASE, AND OTHER NERVOUS SYSTEM DISORDERS WITH PEPTIDE DERIVATIVES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-03-14 | — | — | US | disclosed |