Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097497 | 0.88 | GPR119 (0.42) | GPR119EGLN2JAK1ARJAK2 | |
| SCHEMBL8097494 | 0.88 | GPR119 (0.42) | GPR119EGLN2JAK1ARJAK2 | |
| SCHEMBL8444117 | 0.88 | GPR119 (0.42) | GPR119EGLN2JAK1ARJAK2 | |
| SCHEMBL8096857 | 0.88 | GPR119 (0.42) | GPR119EGLN2JAK1ARJAK2 | |
| SCHEMBL8098378 | 0.77 | CYP11B1 (0.34) | GPR119KDM1ACYP11B1CYP11B2HRH3 | |
| SCHEMBL8098386 | 0.77 | CYP11B1 (0.34) | GPR119KDM1ACYP11B1CYP11B2HRH3 | |
| SCHEMBL8088811 | 0.76 | GPR119 (0.44) | GPR119JAK1JAK2CYP11B1CYP11B2 | |
| SCHEMBL8097797 | 0.75 | CHRM4 (0.35) | GPR119CYP11B1CYP11B2HRH3 | |
| SCHEMBL8097792 | 0.75 | CHRM4 (0.35) | GPR119CYP11B1CYP11B2HRH3 | |
| SCHEMBL8101922 | 0.74 | CYP19A1 (0.34) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127366-A | ANTICARCINOGENIC OR ANTITUMOR AGENTS | MERCK & CO., INC. (US) | 2000-10-03 | — | — | US | disclosed |