Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ERG | P11308 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444117 | 0.87 | GPR119 (0.42) | GPR119CYP11B1CYP11B2JAK2JAK1 | |
| SCHEMBL8096857 | 0.87 | GPR119 (0.42) | GPR119CYP11B1CYP11B2JAK2JAK1 | |
| SCHEMBL8097494 | 0.87 | GPR119 (0.42) | GPR119CYP11B1CYP11B2JAK2JAK1 | |
| SCHEMBL8097497 | 0.87 | GPR119 (0.42) | GPR119CYP11B1CYP11B2JAK2JAK1 | |
| SCHEMBL8103721 | 0.86 | ITGB3 (0.39) | KMT2AGPBAR1ERG | |
| SCHEMBL8104346 | 0.85 | HPGD (0.43) | ALDH1A1KMT2ATSHR | |
| SCHEMBL8088397 | 0.85 | GAA (0.39) | MEN1ALDH1A1KMT2AGPBAR1L3MBTL1 | |
| SCHEMBL8095919 | 0.85 | ALOX12 (0.40) | KMT2AGPBAR1L3MBTL1ERG | |
| SCHEMBL8097865 | 0.84 | L3MBTL1 (0.46) | MEN1ALDH1A1MAPTKMT2AL3MBTL1 | |
| SCHEMBL8097401 | 0.84 | GPR119 (0.43) | GPR119MEN1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127366-A | ANTICARCINOGENIC OR ANTITUMOR AGENTS | MERCK & CO., INC. (US) | 2000-10-03 | — | — | US | disclosed |
| US-5817678-A | IMIDAZOLE-CONTAINING PIPERIDINE DERIVATIVES, PEPTIDEMIMETIC | MERCK & CO., INC. (US) | 1998-10-06 | — | — | US | disclosed |